Chitogel is a post-operative hydrogel nasal dressing that is applied to the sinuses after endoscopic sinus surgery, and addresses a number of traditional sinus surgery challenges.1 1Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald P-J. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Firum Allergy Rhinol. 2018 Mar;8(3):435-443.2 2Athanasiadis T, Beule AG, Robinson BH, Robinson SR, Shi Z, Wormald PJ. Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. Larygoscope. 2008 Jun;118(6):1088-94.
Chitogel reduces ostial stenosis, minimizes adhesions and acts an adjunct to aid in the natural healing process.
Chitogel is easy, efficient and effective to use. Learn how to use Chitogel after endoscopic sinus surgery.
Chitogel improves wound healing through anti-inflammatory action and its ability to delay fibroblast migration.7 7Paramasivan S1, Jones D, Baker L, Hanton L, Robinson S, Wormald PJ, Tan L. The Use of Chitosan-Dextran Gel Shows Anti-Flammatory, Antibiofilm, and Antiproliferative Properties in Fibroblast Cell Culture. Am J Rhinol Allergy. 2014 Sep-Oct;28(5):361-5.
The dual effect of inhibiting inflammation and delaying fibroblast migration provides mechanisms for the anti-adhesion effect of Chitogel, as well as preserving the ostial patency of the sinus ostia.10 10Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ. A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80.
Chitogel also improves the speed of wound epithelialization, with studies showing that this epithelium recovers its ciliated surface, as shown on electron microscopy, significantly faster than where no gel has been used. 2 2Athanasiadis T, Beule AG, Robinson BH, Robinson SR, Shi Z, Wormald PJ. Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis. Larygoscope. 2008 Jun;118(6):1088-94.
This indicates that Chitogel enhances epithelial migration and subsequent functionality, thereby improving the healing time and functioning of the mucosa and contributing to the increased ostial patency when using Chitogel.1 1Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald P-J. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443.
Chitogel reduces ostial stenosis, minimizes adhesions and acts as an adjunct in the natural healing process
Enhances wound healing and is shown to promote healthy sinuses1 1Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald P-J. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443.9 9Megow, A, Alsuliman Y, Bouras G, et al. Chitogel following endoscopic sinus surgery promotes a healthy microbiome and reduces postoperative infections. Int Forum Allergy Rhinol. 2022;1-15
Controls minimal bleeding after sinus surgery3 3Chandra RK, Conley DB, Haines GK, 3rd, Kern RC. Long-term effects of FloSeal packing after endoscopic sinus surgery. American journal of rhinology. 2005;19(3):240-2434 4Kokkevold PR, Lew DS, Ellis DG, Bertolami CN. The effect of chitosan on lingual haemostasis in rabbits. J Oral Maxillofac Surg 1991; 49858-86311 11FDA 510k, Chitogel Endoscopic Sinus Surgery Kit, K172179.510K, Summary.Final
Prevents adhesions between mucosal surfaces in the nasal cavity. 5 5Costain DJ1, Kennedy R, Ciona C, McAlister VC, Lee TD. Prevention of postsurgical adhesions with N, O-carboxymethyl chitosan: examination of the most efficacious preparation and the effect N, O-carboxymethyl chitosan on postsurgical healing. Surgery. 1997 Mar;121(3):314-9.10 10Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ. A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80.11 11FDA 510k, Chitogel Endoscopic Sinus Surgery Kit, K172179.510K, Summary.Final