Publications

Chitogel is clinically proven to significantly reduce ostial stenosis, reduce adhesions and act as an adjunct to aid in the natural healing process.

The development of Chitogel has been supported by a long list of scientific studies, published in international peer-reviewed journals:

Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis.

Athanasiadis T, Beule AG, Robinson BH, Robinson SR, Shi Z, Wormald PJ.

Laryngoscope. 2008 Jun;118(6):1088-94.

The efficacy of a novel chitosan gel on hemostasis after endoscopic sinus surgery in a sheep model of chronic rhinosinusitis.

Valentine R, Athanasiadis T, Moratti S, Robinson S, Wormald PJ.

Am J Rhinol Allergy. 2009 Jan-Feb;23(1):71-5.

The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery.

Valentine R, Athanasiadis T, Moratti S, Hanton L, Robinson S, Wormald PJ.

Am J Rhinol Allergy. 2010 Jan-Feb;24(1):70-5.

Nasal dressings after endoscopic sinus surgery: what and why?

Valentine R, Wormald PJ.

Curr Opin Otolaryngol Head Neck Surg. 2010 Feb;18(1):44-8

The efficacy of hemostatic techniques in the sheep model of carotid artery injury.

Valentine R, Boase S, Jervis-Bardy J, Dones Cabral JD, Robinson S, Wormald PJ.

Int Forum Allergy Rhinol. 2011 Mar-Apr;1(2):118-22. doi: 10.1002/alr.20033.

Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model.

Lauder CI, Garcea G, Strickland A, Maddern GJ. The Journal of surgical research. 2011;171(2):877-82.

Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a porcine hemicolectomy model.

Lauder CI, Strickland A, Maddern GJ. The Journal of surgical research. 2012;176(2):448-54.

The efficacy and safety of chitosan dextran gel in a burr hole neurosurgical sheep model.

Rajiv S, Harding M, Bassiouni A, Jardeleza C, Drilling A, James C, Ha T, Moratti S, Robinson S, Wormald PJ. Acta Neurochir. 2013 Jul;155(7):1361-6

A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery.

Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.

Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80.

Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention.

Cabral JD, Roxburgh M, Shi Z, Liu L, McConnell M, Williams G, Evans N, Hanton LR, Simpson J, Moratti SC, Robinson BH, Wormald PJ, Robinson S.

J Mater Sci Mater Med. 2014 Dec;25(12):2743-56.

The use of chitosan-dextran gel shows anti-inflammatory, antibiofilm, and antiproliferative properties in fibroblast cell culture.

Paramasivan S1, Jones D, Baker L, Hanton L, Robinson S, Wormald PJ, Tan L. Am J Rhinol Allergy. 2014 Sep-Oct;28(5):361-5.

Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention.

Cabral JD, McConnell MA, Fitzpatrick C, Mros S, Williams G, Wormald PJ, Moratti SC, Hanton LR.

J Biomed Mater Res A. 2015 Aug;103(8):2611-20.

Safety and Efficacy of Chitosan-Dextran Hydrogel in the Middle Ear in an Animal Model.

Ünsaler S, Başaran B, Öztürk Sarı Ş, Kara E, Değer K, Wormald PJ.

Audiol Neurootol. 2016;21(4):254-260.

Chitosan Dextran gel as an anti adhesion agent in a postlaminectomy spinal sheep model.

Rajiv S, Drilling A, Bassiouni A, Harding M, James C, Robinson S, Moratti S, Wormald PJ.

J Clin Neurosci. 2017 Jun;40:153-156.

Deferiprone and Gallium-Protoporphyrin Have the Capacity to Potentiate the Activity of Antibiotics in Staphylococcus aureus Small Colony Variants.

Richter, N. Thomas, C. Prestidge, T. Coenye, P.-J. Wormald, S. Vreugde.  Frontiers in Cellular and Infection Microbiology, 2017

A topical hydrogel with deferiprone and gallium-protoporphyrin targets bacterial iron metabolism and has antibiofilm activity

Richter, N. Thomas, J. Claeys, J. McGuane, C. Prestidge, T. Coenye, P.-J. Wormald, S. Vreugde.  Antimicrobial Agents and Chemotherapy, 2017

Safety and Efficacy of Topical Chitogel-Deferiprone-Gallium Protoporphyrin in Sheep Model

Ooi ML, Richter K, Drilling AJ, Thomas N, Prestidge CA, James C, Moratti S, Vreugde S, Psaltis AJ and Wormald P-J.  Front. Microbiol. (2018) 9:917.

The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery.

Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ.

Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443.

Chitogel is improving surgery outcomes and patients’ lives.