Chitogel reduces ostial stenosis, minimizes adhesions and acts as an adjunct to aid in the natural healing process.

Clinically Proven Results

Clinical results show that where Chitogel has been used post surgery, compared to using no packing materials at 12 months post surgery, patients on average experienced the following: 13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443.

73%

Improvement in frontal ostial area

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35%

Improvement in sphenoid ostial area

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34%

Improvement in maxillary ostial area

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47%

Reduction in incidence of adhesion

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50%

Reduction in incidence of edema

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50%

Reduction in incidence of granulation

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Chitogel Reduces Frontal Sinus Ostial Stenosis

Maintenance of frontal sinus ostial patency following endoscopic sinus surgery is critical to the long term success of the procedure.

Unfortunately, ostial stenosis, or the reduction in ostial patency, is a common problem post endoscopic sinus surgery.

The frontal sinus has the highest rate of stenosis, with rates reported of up to 60%.9 9Jacobs JB. 100 years of frontal sinus surgery. Laryngoscope. 1997;107(11 Pt 2):1-36. The frontal sinus is particularly prone to stenosis due to its narrow size, close adjacent surrounding structures such as the skull base and orbit, and residual bony septations after surgery.28 28Friedman M, Landsberg R, Schults RA, Tanyeri H, Caldarelli DD. Frontal sinus surgery: endoscopic technique and preliminary results. Am J Rhinology. 2000;14(6):393-403.

Chitogel Limited, building on the work of an earlier study of chitosan dextran gel26 26A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80. has demonstrated in a recent study by Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide that Chitogel at 12 months post operation is on average nearly twice as effective for maintenance of the original frontal sinus ostial size compared to using no packing materials. In this study the average control frontal ostium shrunk to 37% of the original size while the average Chitogel frontal ostium was 64% of the original size, almost double the size of the control frontal ostium.

The Frontal Ostial results of the Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. study are summarized in the following chart:


Frontal Ostium – Surgery Results Post-op

The following video shows the frontal ostium post operation of a patient who received Chitogel on the right side and no packing materials on the left side:

Non Chitogel Side (left)

Chitogel Side (right)

Chitogel Reduces Sphenoid Sinus Ostial Stenosis

Maintenance of sinus ostial patency following endoscopic sinus surgery is critical to the long term success of the procedure.

Unfortunately, ostial stenosis, or the reduction in ostial patency, is a common problem post endoscopic sinus surgery.

Chitogel Limites, building on the work of an earlier study of chitosan dextran gel has demonstrated in a recent study by Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. that Chitogel at 12 months post operation is on average 35% better at maintaining the original sphenoid sinus ostial size compared to using no packing materials.

In this study at 12 months post operation the average control sphenoid ostium shrunk to 52% of the original size while the average Chitogel sphenoid ostium was 70% of the original size.

The Sphenoid Ostial results of the Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. study are summarized in the following chart:


Chitogel Reduces Maxillary Sinus Ostial Stenosis

Maintenance of sinus ostial patency following endoscopic sinus surgery is critical to the long term success of the procedure.

Unfortunately, ostial stenosis, or the reduction in ostial patency is a common problem post endoscopic sinus surgery.

Chitogel Limited, building on the work of an earlier study of chitosan dextran gel28 28A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80 has demonstrated in a recent study by Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. that Chitogel at 12 months post operation is on average 34% better at maintaining the original maxillary sinus ostial size compared to using no packing materials.

In this study at 12 months post operation the average control maximillary ostium shrunk to 58% of the original size while the average Chitogel maximillary ostium was on average 78% of the original size.

The Maxillary Ostial results of the Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. study are summarized in the following chart:


Maxillary & Sphenoid – Post Surgery Results

The following video shows the sphenoid and maxillary ostia post operation of a patient who received Chitogel on the right side and no packing materials on the left side:

Non Chitogel Side (left)

Chitogel Side (right)

Chitogel  Reduces Post Operative Adhesion Formation

Post-operative adhesions, most commonly between the middle turbinate and the lateral nasal wall, are one of the most common complications after endoscopic sinus surgery. Post-operative adhesions can significantly reduce the effectiveness of the surgery in reducing sinus inflammation and restoring ventilation and drainage of the paranasal sinuses.

Chitogel Limited, building on the work of an earlier study of chitosan dextran gel28 28A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80. has demonstrated in a recent study by Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. that Chitogel at 12 months post operation results in an average 47% reduction in incidence of adhesion compared to using no packing materials. In this study at 12 months post operation the average control side had an incidence of adhesion of 15% while the average Chitogel side had an incidence of only 8%.

The incidence of adhesion results of the Ha et al study13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. are summarized in the following chart:


As the chart shows the incidence of adhesions reduced and the severity of the adhesions has also reduced when using Chitogel.

Adhesions – Post Surgery Results

The following video shows the difference in adhesions in a patient who received Chitogel on the left side and no packing materials on the right side:

Control Side (left)

Chitogel Side (right)

Proven Adjunct To Aid The Natural Healing Process


The effectiveness of the natural healing process post endoscopic sinus surgery can be indicated by a number of factors including the level of edema, granulation, pus and crust formation.

Chitogel Limited, building on the work of an earlier study of chitosan dextran gel28 28A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery. Ngoc Ha T, Valentine R, Moratti S, Robinson S, Hanton L, Wormald PJ.Int Forum Allergy Rhinol. 2013 Jul;3(7):573-80. has demonstrated in a recent study by Ha et al13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. that Chitogel at 12 months post operation reduced the incidence of edema, granulation, pus and crust formation when compared to using not packing materials.

Reduction in incidence of Edema

The reduction in the incidence of edema results of the Ha et al study13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. are summarized in the following chart:


As the chart shows the incidence of edema reduced by 50% when using Chitogel.

Edema – Post Surgery Results

The following video shows the difference in edema in a patient who received Chitogel on the left side and no packing materials on the right side:

Chitogel Side (left)

Non Chitogel Side (right)

Reduction in incidence of Granulation

The reduction in the incidence of granulation results of the Ha et al study 13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. are summarized in the following chart:


As the chart shows the incidence of granulation reduced and the severity of the granulation has also reduced when using Chitogel.

Granulation and Edema – Post Surgery Results

The following video shows the difference in granulation in a patient who received Chitogel on the left side and no packing materials on the right side:

Chitogel Side (left)

Non Chitogel Side (right)

Reduction In Incidence Of Crust Formation

The reduction in the incidence of crust formation results of the Ha et al study1 1Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. are summarized in the following chart:


As the chart shows the incidence of crust formation reduced and the severity of the crust formation has also reduced when using Chitogel.

Crust Formation – Post Surgery Results

The following video shows the difference in crust formation in a patient who received Chitogel on the left side and no packing materials on the right side:

Chitogel Side (left)

Non Chitogel Side (right)

Reduction In Incidence Of Pus Formation

The reduction in the incidence of pus formation results of the Ha et al study13 13Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443. are summarized in the following chart:


As the chart shows the incidence of pus formation reduced when using Chitogel.