30 million Americans suffer from sinusitis, living with inflammation or swelling of the sinuses and nasal cavity.1 1Summary Health Statistics for U.S. Adults: National Health Interview Survey, 2012. Patients with chronic sinusitis often suffer from a range of symptoms which significantly reduce their enjoyment of life.2 2Tomblinson CM, Cheng MR, Lal D, and Hoxworth JM. The impact of middle turbinate concha bullosa on the severity of inferior turbinate hypertrophy in patients with a deviated nasal septum. AJNR Am J Neuroradiol 37:1324-1330, 2016.,3 3Barakate M, and Havas T. Surgical management of paediatric chronic rhinosinusitis: Review of 10 years’ experience. J Laryngol Oto! 128(suppl. 2):S43-S47, 2014.
Many patients with chronic sinusitis whose conditions fail to respond to medical treatment require surgery to return their sinus cavities to normal. Chitogel is a highly effective surgical gel designed to significantly improve surgical outcomes in the treatment of sinusitis.
Sinus surgery is often less successful than desired with problems arising when openings narrow or close off (stenosis) due to scar tissue forming:
Removable nasal packing has been the traditional method of preventing adhesion formation following ESS. However it is rated by patients as the most unpleasant and painful aspect of the ESS experience18 18Chandra RK, Kern RC. Advantages and disadvantages of topical packing in endoscopic sinus surgery. Current Opinions in Otolaryngology Head Neck Surgery. 2004;12(1):21-26., and is associated with significant mucosal trauma as the packing is removed.19 19Shaw CL, Dymock RB, Cowin A, Wormald P-J. Effect of packing on the nasal mucosa of sheep. Journal of Laryngology and Otology. 2000;114:506-509.
Novel absorbable nasal packing agents have been developed in recent years but have not shown a significant decrease in adhesion formation.20 20Chandra RK, Conley DB, Haines GK, 3rd, Kern RC. Long-term effects of FloSeal packing after endoscopic sinus surgery. American journal of rhinology. 2005;19(3):240-243.,21 21Maccabee MS, Trune DR, Hwang PH. Effects of topically applied biomaterials on paranasal sinus mucosal healing. Am J Rhinology. 2003;17(4):203-207.
If ESS is unsuccessful then a recurrence of the symptoms of sinus disease will often follow. Subsequently additional medical treatment and revision surgical procedures are often required.
Chitogel is clinically proven to significantly reduce ostial stenosis, reduce adhesions and act as an adjunct to aid in the natural healing process.
Clinical results show that where Chitogel has been used post surgery compared to using no packing materials at 12 months post surgery, patients on average experienced the following: 24 24Ha T, Valentine R, Moratti S, Hanton L, Robinson S, Wormald PJ. The efficacy of a novel budesonide chitosan gel on wound healing following endoscopic sinus surgery. Int Forum Allergy Rhinol. 2018 Mar;8(3):435-443.